Makemikari Akakosha eZvigadzirwa zvedu
Ashwagandha
Ashwaganda ndeye Ayurvedic Herb inozivikanwawo naAnania Somnifera inoshandiswa senzira yakakura yekugadzirisa muIndia kwemazana emakore (Pratte M et al, 2014).
Miriwo inorondedzerwa se adaptogen, inoratidza kugona kwayo kugadzirisa maficha uye nekudaro kudzikamisa kupindura kwemuviri kunetseka (Provino R, 2010). Ashwagandha ine chinetso chekuzvidya mwoyo mumhuka nevanhu. Yakarongedzwa yakapofumara yakapofumara, placebo inodzora kudzidza kwekuchengetedza uye kushanda kweiyo yakakwira yakatarisana yakazara yakazara dhisiki yeashwagandha midzi mukuderedza kushushikana uye kushushikana muvakuru (Chandrasekhar K et al, 2012) yakaratidza kuti 600mg yeashwagandha yakatorwa kwemazuva makumi matanhatu muvanhu vane chirwere chisingaperi. kushushikana kwepfungwa kwakakwanisa kugadzirisa ese akaedzwa parameter uye yakaderedza serum cortisol ne60%.
Tsvagiridzo inoratidza zvakare kuti yakatoratidzira kuva nemhedzisiro mukushushikana kwakafanana neiyo yemhando benzodiazepines (Pratte M et al, 2014). Imwe ongororo ichangoburwa (Lopresti A et al, 2019) yakaratidza kuti kutora dosi yezuva nezuva ye240 mg yeAshwagandha kwakadzora zvakanyanya kushushikana kwevanhu kana ichienzaniswa ne placebo. Izvi zvaisanganisira kudzikiswa kwemazinga ecortisol inova iyo yekushushikana kemikari.
Bacopa
Bacopa monnieri mushonga we nootropic uyo wakashandiswa mukurapa kwechinyakare kwehupenyu hwakareba uye kusimudzira kwekuziva. Kuwedzera Bacopa kunogona kudzikisa kushushikana uye kugadzirisa kurangarira kuumbwa.
Chidzidzo che2008 (Calabrese C et al, 2008) pamhedzisiro yechigadziro chakatemwa cheBacopa pakuziva mashandiro, kushushikana uye kushushikana muvanhu kwakaratidza kuvandudzika kukuru mukutarisa (kashoma kuti vateerere ruzivo rusina basa), kushanda ndangariro uye zvishoma kufunganya uye kuora mwoyo. Izvo zvinogona zvakare kucherechedzwa kuderera kwemoyo kurovera pasina shanduko muropa
Kuwedzera kune izvi ongororo ichangoburwa (Benson S et al, 2013) kuongorora muyero weBacopa pane multitasking kusagadzikana kushushikana uye kushushikana kwakaratidza kuti muyero we640mg yemiriwo zvichikonzera kudzikira kukuru mumazinga ecortisol mumaawa mashoma kana maviri apfuura kuitora.
GABA
Gamma-Aminobutyric acid iamino acid inogadzirwa zvakasikwa muuropi. GABA inoshanda seyurotransmitter, ichifambisa kutaurirana pakati pemasero ehuropi. Basa rakakura raGABA mumuviri kudzora mashandiro emauroni muuropi uye nepakati tsinga system, iyo inova nemhedzisiro yakawanda panyama nepfungwa, kusanganisira kuwedzera kuzorora, kushushikana kwakadzikira, kudzikama, kudzikama, kurerutsa kurwadziwa, uye kukurudzira kurara.
Basa reiyo inhibitory neurotransmitter GABA yakagara ichionekwa senge iri pakati pekugadzirisa kushushikana uye ino neurotransmitter system ndiyo inotarisirwa benzodiazepines nemishonga inoenderana nayo inoshandiswa kurapa kusagadzikana kwekushushikana (Nuss P, 2015).
L-theanine
L-Theanine isiri proteinaceous amino acid inowanzo kuwanikwa mu green tii iyo yanga ichibatanidzwa neakawanda ehutano mabhenefiti kusanganisira kusimudzira kwemanzwiro, kugona uye kudzikisira kwekuzvidya-kufanana nezviratidzo (Everett JM et al, 2016).
Everett JM et al (2016) akaongorora mashanu akasarudzika akaedzwa akayedzwa aisanganisira 104 vatori vechikamu vachinanaira mbongoro L-theanines kushandiswa zvine chekuita nekushushikana uye kusagadzikana. Zvidzidzo zvakawana kuti paive nekudzikiswa kuri pachena muzviratidzo izvi apo thiamine yaidyiwa zuva nezuva. Chidzidzo chekuwedzera chakanangana nevanhu vanorarama nemamiriro akakomba senge schizophrenia uye schizoaffective kusagadzikana. Tsvagiridzo yakawana kuti L-theanine yakadzora kushushikana uye nekuvandudza zviratidzo (Ritsner M et al, 2009).
5-HTP
5-HTP (5-hydroxytryptophan) kemikari ne-chigadzirwa cheprotein chivakwa L-tryptophan. Inogadzirwawo zvekutengesa kubva pambeu yemuti wemuAfrica unozivikanwa seGriffonia simplicifolia.
5-HTP inoshanda muuropi uye yepakati tsinga system nekuwedzera kugadzirwa kwemakemikari serotonin. Serotonin inogona kukanganisa kurara, kuda kudya, kupisa, kuita zvepabonde, uye kurwadziwa kwekunzwa. Sezvo 5-HTP ichiwedzera iyo synthesis yeserotonin, inoshandiswa pazvirwere zvinoverengeka uko serotonin inofungidzirwa kuti inoita basa rakakosha kusanganisira kushushikana, kushaya hope, kufutisa, uye zvimwe zvakawanda mamiriro.
Chidzidzo chakaitwa naPediatr E (2004) chakanangana nekuongorora kushandiswa kwe5-HTP pakurapa zvinotyisa kuvana. Mhedzisiro yakawanikwa 2mg / kg ye5-HTP kwemazuva makumi maviri yaive yakabatana neakanyanya kushomeka kwekurara panguva yekuwedzera uye kusvika kumwedzi mitanhatu mumashure.
Mint
Peppermint (Mentha × piperite) mushonga unonhuhwirira mumhuri yemindi inova muchinjikwa pakati pemvura uye pfumo. Native kuEurope neAsia, yanga ichishandiswa kwezviuru zvemakore nekuda kweinofadza, minty kuravira uye hutano hunobatsira. Peppermint inoshandiswa kune akawanda akasiyana zvinangwa asi zvakanyanya kukosha, inoratidzwa kunatsiridza kurara (Groves M, 2018).
Kuongororwa kweiyo bioactivity uye inogona kuve hutano mabhenefiti epeppermint tii (Mckay D naBlumberg J, 2006) yakaratidza peppermint tii kuve mhasuru inozorodza iyo inogona kushandiswa kuzorora usati warara.
Rhodiola
Rhodiola mushonga unomera munzvimbo dzinotonhora, dzemakomo eEurope neAsia. Midzi yawo inoonekwa se adaptogens, zvichireva kuti ivo vanobatsira muviri wako kujairira kunetseka kana uchinge wadya. Rhodiola inozivikanwa zvakare seArctic midzi kana mudzi wegoridhe, uye zita rayo resainzi iri Rhodiola rosea (Res P, 2015).
Midzi yawo ine zvinopfuura zvinoshanda zana nemakumi mana nezvinomwe, iwo maviri akasimba ayo ari rosavin uye salidroside. Vanhu muRussia nenyika dzeScandinavia vakashandisa rhodiola kurapa kushushikana, kuneta uye kushushikana kwemazana emakore.
Imwe ongororo yakaongorora mhedzisiro yeRhodiola mushoma muvanhu zana negumi vane kushushikana kwehupenyu- uye nebasa. Vatori vechikamu vakapihwa 101 mg pazuva kwemavhiki mana (Res, P 400). Yakawana kuvandudzwa kwakakosha muzviratidzo zvekushushikana, senge kuneta, kupera simba uye kushushikana, mushure memazuva matatu chete. Idzi gadziridzo dzakapfuurira mukudzidza kwese.
References:
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Provino R. Basa re adaptogens mukutonga kwekushushikana. Aust J Med Mishonga 2010; 22: 41-49
Bhattacharya S, Muruganandam A.Adaptogenic chiitiko chaAndania somnifera: chidzidzo chekuyedza uchishandisa rat rat yemhando yekushushikana kusingaperi. Pharmacol Biochem Behav 2003; 75: 547-555
Lopresti A, Smith S, Malvi H naKodgule R. Kuongorora nezvekushushikana-kurerutsa uye zviitwa zvezvemishonga zveashwagandha (Withania somnifera) bvisa. Mushonga (Baltimore) 2019.
K Chandrasekhar , Jyoti Kapoor, Sridhar Anishetty. Inotarisirwa, yakasarudzika yakapofumara-yakapofumara, yekumusoro-inodzorwa yekuchengetedza uye kushanda kweiyo yakakwira-yakazara yakazara-dhizaini yeashwagandha midzi mukuderedza kusagadzikana uye kunetseka kune vanhu vakuru. Indian J Psychol Med 2012 Jul; 34 (3): 255-62
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Benson S, Downey L, Stough C, Wetherell M, Zangara A uye Scholey A. An acute, double-blind, placebo-controlled-cross-over kudzidza nezve 320 mg uye 640 mg doses yeBacopa monnieri (CDRI 08) pane multitasking kusagadzikana kunetseka uye mafungiro. Phytother Res. 2014 Kubvumbi; 28 (4): 551-9.
Ritsner M, Miodownik C, Ratner Y, Shleifer T, Mar M, Pintov L naLerner V. L-Theanine Anobvisa Zviratidzo, Kuita, uye Kunetseka Zviratidzo muvarwere vane Schizophrenia uye Schizoaffective Disorder: An 8-Svondo, Randomized, Double-Blind , Placebo-Inodzorwa, 2-Center Study. Iyo Zvinyorwa zveKiriniki Psychiatry. Schizophrenia uye Schizoaffective. 2009.
Everett JM, Gunathilake D, Dufficy L, Roach P, Thoas J, Thomas J, Upton D, NAumovski N. Theanine kushandiswa, kushungurudzika uye kuzvidya mwoyo mumakiriniki emunhu miedzo: Kuongorora kwakarongeka. Zvinyorwa zveNutrition uye Intermediary Metabolism. Vol 4, mapeji 41 - 42. 2016.
Pediatr E. L -5-Hydroxytryptophan kurapwa kwekutyisa kwekurara muvana. National Raibhurari yeMishonga. 163 (7): 402-7 2004.
Res P. Kurapa mhedzisiro uye kuchengetedzeka kweRhodiola rosea kubvisa WS® 1375 mune zvidzidzo zvine hupenyu-kushushikana zviratidzo - mhedzisiro yeakavhurika-chitambi kudzidza. National Raibhurari yeMishonga. Mbudzi 26 (8): 1220-5 2012.
Res P. Mhedzisiro yeRhodiola rosea L. Bvisa pane Kushushikana, Kushushikana, Kuziva uye Zvimwe Zviratidzo zveMood. National Raibhurari yeMishonga. 29 (12): 1934-9 (2015).